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Exploring Psychedelic Assisted Therapy: Medicines, Preparation, Sessions, and Integration

  • Writer: Jovie Peralta
    Jovie Peralta
  • May 31
  • 3 min read

Psychedelic assisted therapy is gaining attention as a promising approach to address mental health challenges, including trauma, depression, and anxiety. This form of therapy combines the use of specific psychedelic medicines with guided therapeutic support to help individuals explore their inner experiences and promote healing. Understanding how this therapy works, the medicines involved, and the process from preparation to integration can help potential clients make informed decisions about their mental health journey.



Eye-level view of a serene therapy room with soft lighting and comfortable seating


Common Psychedelic Medicines Used in Therapy


Several psychedelic substances have shown potential in assisted therapy settings. The most studied, and decriminalized in Colorado include:


  • Psilocybin (Not federally legal, however decriminalized in CO)

Derived from certain species of mushrooms, psilocybin has been researched for its ability to reduce symptoms of depression, anxiety, and PTSD. It works by temporarily altering brain connectivity, allowing new perspectives on personal challenges.


  • DMT (Not federally legal, however decriminalized in CO)

    Derived from various plants and found in the human body, DMT is known for producing quick but intense somatic sensations as well as a relaxing and calming effect. Its inhaled effects typically last only 5 to 15 minutes, making it one of the shortest-acting psychedelics.


  • Ketamine (federally legal and can be obtained with a prescription)

Although not a classic psychedelic, ketamine produces dissociative effects that can help patients access difficult emotions and memories. It is often used in clinical settings for treatment-resistant depression and trauma-related conditions.


  • MDMA (not legal or decriminalized, however clinical studies have begun)

Known for its empathogenic effects, MDMA is used in therapy to reduce fear and defensiveness, making it easier for clients to process trauma.


Each medicine has a unique profile, duration of effects, and therapeutic potential. Licensed professionals carefully select the appropriate substance based on individual needs and medical history.


Preparation Sessions: Setting the Stage for Healing


Preparation is a critical phase in psychedelic assisted therapy. These sessions help build trust between the client and therapist and establish clear goals for the experience. Key elements include:


  • Education about the medicine

Clients learn what to expect during the session, including possible emotional and physical sensations.


  • Setting intentions

Defining personal goals helps guide the therapy. For example, someone might focus on healing from past trauma or breaking negative thought patterns.


  • Building rapport

A strong therapeutic relationship ensures clients feel safe and supported throughout the process.


  • Discussing safety and logistics

This includes medical screening, planning the session environment, and addressing any concerns.


Preparation sessions usually involve multiple meetings and may include mindfulness or grounding exercises to help clients feel centered before the medicine session.


The Medicine Session: Guided Exploration


The core of psychedelic assisted therapy is the medicine session itself. This is when the client takes the psychedelic substance under professional supervision. The environment is carefully controlled to promote comfort and safety. In CO, psilocybin assisted therapy must be done in a healing center with a licensed professional.


During the session:


  • Clients often lie down or sit comfortably, sometimes with eyes closed, to focus inward.

  • Therapists provide support but generally allow the experience to unfold naturally.

  • Music or other sensory elements may be used to enhance the journey.

  • The session length varies depending on the medicine: psilocybin experiences typically last 4 to 6 hours, while ketamine sessions are shorter, around 40 minutes to an hour.


The goal is not to control the experience but to help clients process emotions, memories, or insights that arise. Many report profound shifts in perspective and emotional release.


Integration Sessions: Making Sense of the Experience


After the medicine session, integration is essential to translate insights into lasting change. These sessions help clients reflect on their experience and apply new understanding to daily life.


Integration work may include:


  • Discussing the session

Clients share what they experienced, including any difficult moments or breakthroughs.


  • Therapeutic processing

Therapists help interpret visions, emotions, or memories that surfaced.


  • Developing coping strategies

Clients learn tools to maintain mental health improvements and manage challenges.


  • Setting future goals

Integration supports ongoing growth beyond the therapy.


Without integration, the benefits of psychedelic assisted therapy may be limited. This phase ensures that the experience leads to meaningful healing and personal development.



 
 
 

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Saela Ro Therapy & Wellness is the DBA of parent company JP Therapy Services, LLC.

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